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                                                                              鞠建华团队解析β-咔啉生物碱時間合成机制

                                                                              发布者:超级管理员  发布时间:2014-01-13 09:56:00  浏览:
                                                                               
                                                                              本报讯(记者李洁尉 通讯员陈忠)记者日前从中科院但是發出南海海洋所获悉,该所鞠建华团队成功解析了深海微生物来源的β-咔啉生物碱的生物可你認為你躲得過我這雙眼睛嗎合成机制。相关成果近日发表在《应用化学》杂志上。随后,Faculty of 1000对该成果进行了推荐。
                                                                               
                                                                              据介绍,研究人员从一株南海深海放线菌中分离得到5个海洋β-咔啉生物碱类化合物確實是這樣(1~5),并成功定位了基因组上的一段DNA序列编码,分别为编码酰胺键□合成酶的基因mcbA、未知功∮能基因mcbB和编码脱羧酶的基明天繼續因mcbC。
                                                                               
                                                                              研究还证明,McbB蛋白负责β-咔啉骨架的形成,是一个催化该类母核形成的新颖的Pictet-Spengler反应酶。这≡对阐明其他β-咔啉生物碱的生物合成途径 那我們這次包圍一線天具有重要指导意◥义。
                                                                               
                                                                              《中国科学报》 (2013-12-12 第4版 综合)

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